IndicationSuspected autoimmune arterial and / or venous thrombosis, thrombocytopenia, and repeated abortions. This is seen in primary antiphospholipid syndrome (APS) and systemic lupus erythematous with secondary anti-phospholipid syndrome (APS).MethodThe analysis is performed by ELISA. Answers are given both in IgG and IgM antibodies.
AnswerThe result is reported as negative or positive with a value.
InterpretationElevated levels of antibodies against β 2-Glycoprotein-1 (>30 U/ml) at two sampling occasions with at least 12 weeks interval is a marker for the anti-phospholipid syndrome (APS) that is characterized by recurrent arterial and/or venous thrombosis, and/or recurrent miscarriages. APS is often associated with SLE (secondary APS) but may also be seen without associated inflammatory disease (primary APS).
If suspicion of APS persists in case of negative results for lupus anticoagulant, IgG and / or IgM antibodies to anti-beta2-Glycoprotein-1 and / or cardiolipin, it is recommended to analyze IgA-class antibodies against beta2-Glycoprotein-1 and Cardiolipin, which has been reported to occur in isolated cases. Antibodies against phosphatidylserine may also be of value.